Screening of edible plants against possible anti-tumor promoting activity
Identifieur interne : 003F82 ( Main/Exploration ); précédent : 003F81; suivant : 003F83Screening of edible plants against possible anti-tumor promoting activity
Auteurs : Koichi Koshimizu [Japon] ; Hajime Ohigashi [Japon] ; Harukuni Tokuda [Japon] ; Akira Kondo [Japon] ; Kanoko Yamaguchi [Japon]Source :
- Cancer Letters [ 0304-3835 ] ; 1988.
Abstract
One hundred twenty-one species of edible plants (133 test-parts) were screened against possible anti-tumor promoting activity by an in vitro shortterm assay system of inhibition of Epstein-Barr virus (EBV) activation induced by a phorbol-ester promoter, 12-O-hexadecanoylphorbol-13-acetate (HPA). The methanol-extracts (ME) of 14 species of the edible plants strongly inhibited the activation, 7 moderately and 12 weakly inhibited it. On partition of the randomly selected inactive ME (26 species) with ethyl acetate and water, 13 and 2 species were active, more or less, in the ethyl acetate and water soluble part, respectively. Thus, this result suggested that anti-tumor promoters occur in a wide variety of edible plants. The anti-tumor promoting activity in the crude extacts may be enhanced or reduced with co-occurring factors acting additively, synergistically or antagonistically.
Url:
DOI: 10.1016/0304-3835(88)90067-5
Affiliations:
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type="ISSN">0304-3835</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One hundred twenty-one species of edible plants (133 test-parts) were screened against possible anti-tumor promoting activity by an in vitro shortterm assay system of inhibition of Epstein-Barr virus (EBV) activation induced by a phorbol-ester promoter, 12-O-hexadecanoylphorbol-13-acetate (HPA). The methanol-extracts (ME) of 14 species of the edible plants strongly inhibited the activation, 7 moderately and 12 weakly inhibited it. On partition of the randomly selected inactive ME (26 species) with ethyl acetate and water, 13 and 2 species were active, more or less, in the ethyl acetate and water soluble part, respectively. Thus, this result suggested that anti-tumor promoters occur in a wide variety of edible plants. The anti-tumor promoting activity in the crude extacts may be enhanced or reduced with co-occurring factors acting additively, synergistically or antagonistically.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><country name="Japon"><region name="Région du Kansai"><name sortKey="Koshimizu, Koichi" sort="Koshimizu, Koichi" uniqKey="Koshimizu K" first="Koichi" last="Koshimizu">Koichi Koshimizu</name></region><name sortKey="Kondo, Akira" sort="Kondo, Akira" uniqKey="Kondo A" first="Akira" last="Kondo">Akira Kondo</name><name sortKey="Ohigashi, Hajime" sort="Ohigashi, Hajime" uniqKey="Ohigashi H" first="Hajime" last="Ohigashi">Hajime Ohigashi</name><name sortKey="Tokuda, Harukuni" sort="Tokuda, Harukuni" uniqKey="Tokuda H" first="Harukuni" last="Tokuda">Harukuni Tokuda</name><name sortKey="Yamaguchi, Kanoko" sort="Yamaguchi, Kanoko" uniqKey="Yamaguchi K" first="Kanoko" last="Yamaguchi">Kanoko Yamaguchi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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